Fig. 4
Spontaneous single-unit firing rate in hindlimb cortex 4–18 weeks following spinal cord injury. Mean spontaneous firing rates of isolated single-units in layers Va, Vb, and VI of the hindlimb motor cortex in control rats (n = 5) and rats with a spinal cord contusion at T9-10 (n = 14). Laminar estimates are based on the depths of electrode sites on a single-shank multi-electrode array relative to the cortical surface26. In each rat, single-unit (spike) activity was sampled from 4 to 6 locations within neurophysiologically identified hindlimb motor cortex. Data represent the mean firing rates of 1744 isolated units in Layers Va (control, n = 124; SCI, n = 312), Vb (control, n = 155; SCI, n = 390), and VI (control, n = 217; SCI, n = 546). Two-tailed t-test, t = 3.99, ****p < 0.0001
