Fig. 1
From: Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
Loss of Pofut1 causes coronary artery anomalies and ischemic heart disease. a Survival curve shows ~80% Nfatc1 Cre;Pofut1f/f (Pofut1 cKO) mice die by P120. b Gross view of a dilated P60 Pofut1 cKO heart. c Heart/body ratio. *p < 0.01. d Echocardiography showing reduced cardiac functions in P60 Pofut1 cKO heart. *p < 0.001. e qPCR showing reversed expression changes of Myh6 and Myh7 in P21 Pofut1 cKO hearts. *p < 0.01. f Gross view of a large myocardial infarct (circle) at the apex of a P34 Pofut1 cKO heart. g Cardiac histology showing cardiac necrosis and fibrosis in a P34 Pofut1 cKO heart. h Hypoxia staining showing expansion of inner myocardial hypoxia in young Pofut1 cKO mice. i MicroCT shows coronary anomalies with hypoplastic main arteries and aneurisms (arrow). j PECAM1 staining shows increased primitive coronary plexuses in a P15 Pofut1 cKO heart. All bar charts represent mean ± s.d
