Fig. 5
Effects of Oxtr deletion on excitatory and inhibitory synaptic transmission of newly generated DGCs. a Representative traces of sEPSCs recorded from newly generated DGCs in slices from WT and Oxtr −/− mice at 14 dpi. b, c Cumulative probability plots of sEPSC b interevent intervals and c amplitude (n = 6 neurons from 4 mice per genotype, Kolmogorov-Smirnov test) in newly generated DGCs from WT and Oxtr −/− mice at 14 dpi. d, e Summary bar graphs depicting the averaged d frequency and e amplitude of sEPSCs in newly generated DGCs from WT and Oxtr −/− mice at 14 dpi (n = 6 neurons from 4 mice per genotype; *P < 0.05, unpaired two-tailed Student’s t test). f Left panel, Sample traces of evoked IPSCs recorded at different holding potentials ranging from −70 to −20 mV (10 mV step) from newly generated DGCs in slices from WT and Oxtr −/− mice at 10 dpi. Right panel, current-voltage plot of the peak current of evoked IPSCs obtained from the sample traces. g Summary data comparing the reversal potential of GABA-mediated IPSCs (EGABA) of newly generated DGCs from WT and Oxtr −/− mice at 10, 14, and 28 dpi (n = 4–5 neurons from 4 mice for each group; *P < 0.05, **P < 0.01, two-way ANOVA with Bonferroni’s post hoc test). h Summary data comparing the calculated intracellular chloride concentrations ([Cl−]i) in newly generated DGCs from WT and Oxtr −/− mice at 10, 14, and 28 dpi (n = 4–5 neurons from 4 mice for each group; *P < 0.05, ***P < 0.001, two-way ANOVA with Bonferroni’s post hoc test). Data represent the mean ± s.e.m
