Fig. 10 | Nature Communications

Fig. 10

From: Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Fig. 10

Tumor-released Hsp70 and Hsp90-expressing EVs mediate systemic increase of inflammatory cytokines. Sera from mice bearing LLC tumor with or without knockdown of Rab27 on days 0, 7, 14 and 21 of tumor cell implant were analyzed for levels of Hsp70, Hsp90 and EVs as described above, and TNFα, IL6 and IL-1β using Bio-Plex® Multiplex Immunoassays. For Hsp70/90 measurement sera were treated with Brij98 before ELISA. Data (n = 6) were analyzed by analysis of variance. * denotes a difference (P < 0.05)

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