Fig. 9
From: Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
TLR4 is critical to Hsp70/Hsp90-induced muscle wasting in mice. a Hsp70 and Hsp90-induced muscle catabolism in mice is dependent on TLR4. Wild-type and TLR4 null mice were injected with rHsp70 and rHsp90 and analyzed for catabolic response in TA as described in Fig. 4. b Hsp70 and Hsp90-induced muscle wasting is TLR4-dependent. Wild-type and TLR4 null mice injected with rHsp70 and rHsp90 are further analyzed for muscle wasting. Scale bar, 100 μm. Data (n = 5) were analyzed by analysis of variance or χ 2 analysis (for CSA). * denotes a difference (P < 0.05)
