Fig. 5 | Nature Communications

Fig. 5

From: Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children

Fig. 5

Serological responses to natural EV71 infection in children. a Post-infection sera from three mAb donors (day 9 serum from donor M and day 11 sera from donors Y and Z) were tested for neutralization of wild-type and escape mutants of EV71. b Post-infection sera from pediatric patients with laboratory-confirmed EV71 infection were tested against the wild-type virus and escape mutants. The figure shows a comparison of the neutralization titers against EV71 12-96015 and 11-96023 between two sera groups (Mann–Whitney test). The symbols in the figure represent one particular subject (i.e., solid circles are donor Y and solid diamonds are donor Z). c Of the 27 post-infection serum samples, 16 (59%) and 7 (26%) showed a ≥ 8-fold reduction in neutralization titer against at least one 12-96015 and 11-96023 escape mutant, respectively. The percentages of samples that were reactive to each epitope are shown. Black lines represent the mean ± standard error of the mean. All samples were tested in duplicate from two independent experiments

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