Fig. 7

Schematic of proposed mechanism. Anchors with weak and rapid interactions with the matrix can facilitate more effective crosslinking of nanoparticulates to matrix constituents compared to anchors with high-affinity, long-lived interactions with the matrix. The extent that the motion of nanoparticulates are hindered by different anchors are reflected by the dimensions of their traces (black). Red circles/arrows indicate the small fraction of free (not particle-bound) anchors that will transiently interact with the matrix at any moment in time