Fig. 3
From: Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
Class B PBPs from Gram-negative and Gram-positive display similarities at key interfaces. a PBP2 from H. pylori, this work, b PBP2b from S. pneumoniae (2WAD), c PBP2x from S. pneumoniae (1RP5), d PBP3 from P. aeruginosa (3PBN) harbor anchor (red) and head (blue) regions stabilized by hydrophobic interactions, which could be disrupted and reoriented upon binding to a partner PG-biosynthesis molecule (such as MreC). An Arg-Arg-Glu constellation, indicated here in magenta, is present in the structures of all class B PBPs solved to date, and sits at the interface between anchor and head
