Fig. 2

Five main effect results with uncorrected p value < 0.0001. Main effect analysis was performed for 33,683 SNPs and 3374 samples (835 cases, 2539 controls) using logistic regression in PLATO. This Synthesis View58 plot denotes the SNP (nearest gene) on the left and the track to the right displays the –log10 of the uncorrected main effect p value. The red line denotes the Bonferroni threshold for corrected significance (uncorrected p: 1.48 × 10−6; α = 0.05, 33,683 tests)