Fig. 4
Top main effect filtered and Biofilter G×G results. a SNP–SNP analysis was performed for 32,640 main effect filtered models and 3374 samples (835 cases, 2539 controls) using logistic regression in PLATO. This Synthesis View58 plot denotes the SNPs (nearest genes) on the left and the track to the right displays the –log10 of the uncorrected LRT p value. The red line denotes the Bonferroni threshold for corrected significance (uncorrected LRT p: 1.53 × 10−6; α = 0.05, 32,640 tests). b SNP–SNP analysis was performed for 404 Biofilter models and 3374 samples (835 cases, 2539 controls) using logistic regression in PLATO. This Synthesis View58 plot denotes the SNPs (nearest genes) on the left and the track to the right displays the –log10 of the uncorrected LRT p value. The red line denotes the Bonferroni threshold for corrected significance (uncorrected LRT p: 1.24 × 10−4; α = 0.05, 404 tests)
