Fig. 1

Structural and schematic representations of the IL-1α/SL1067 complex and SL1067. a Overall structure of the IL-1α/SL1067 complex. IL-1α is colored green and SL1067 is colored cyan with the 2Nap modified residues colored orange. b Sequence alignment of IL-1α and IL-1β. IL-1α residues that are involved in the non-polar and polar interactions with SL1067 are denoted with black stars and triangles separately. c Side view of the SL1067 structure. The Nap modified nucleotides are colored orange. d Schematic representation of SL1067. The three parts of SL1067: stem, turn, and loop are marked. All the base pairs are labeled according to the nomenclature of Leontis et al.²⁶