Fig. 8

Abundance differences in specific gut microbial KOs in ACVD and other diseases. a Enzymes for production of SCFAs. b Enzymes for TMA production. CutD is an activator for CutC. The cohort names were colored according to the direction of enrichment, i.e. green and red for control- and case-enriched, respectively within each disease cohort (ACVD, total n = 405 including 218 cases; Cirrhosis, total n = 231 including 120 cases; Obesity, total n = 151 including 72 cases; T2D, total n = 345 including 171 cases; RA, total n = 169 including 95 cases). Wilcoxon rank-sum test, P-value < 0.01; light green and light red, Wilcoxon rank-sum test 0.01 ≤ P-value < 0.05; black, P-value ≥ 0.05. Boxes represent the median and interquartile ranges (IQRs) between the first and third quartiles; whiskers represent the lowest or highest values within 1.5 times IQR from the first or third quartiles. Circles represent all data points