Fig. 4
From: MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Binding potential (BP) images of 11C-PK11195 in positron emission tomography (PET). a Representative slices of BP images sectioned coronally and axially are shown for all animals and time points before (Pre) or after transplantation (1W, 1M, 2M, and 3M). b Chronological change of BP in the left (grafted side) and right (control side) putamen of each monkey. BP values ranging from 0 to 1 are presented with the color bar. c Spearman correlation analyses of 11C-PK11195 PET at 3 months and immunohistological results at 4 months. BP in each grafted putamen plotted vs. the average immunohistochemical results of Iba-1, CD45, MHC Class II, and IgG deposits from individual animals. Results from Spearman correlation analysis are given as r- and P-values in each graph. Tendencies of correlations are shown by linear regression lines for CD45 and IgG deposits. M months after transplantation, O.D.: optical density of the whole putamen, PK: 11C-PK11195, pre: preoperative analysis, W: weeks after transplantation
