Fig. 1
From: Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder
Activating mutations in NRF2 are associated with supratentorial white matter signal changes on MRI. T2 weighted images (a, patient 1) or FLAIR (b, patient 2 and c, patient 3) from three patients showing multiple smaller single or larger confluent hyperintense lesions. d Colorcoded MT sat maps overlayed onto the corresponding T1-weighted image of patient 1 (left) and age- and gender-matched healthy control (right). Note the distinct reduction of MT sat within the white matter lesions most pronounced in the occipital regions displaying values close to gray matter. Color scale with the respective MT sat values on the right
