Fig. 2

Identification of molecular subtypes of HCC using CNVcor and METcor genes. a, b Plots show the non-negative factorization (NMF) cluster results for the CNVcor in CNV data (a) and for the METcor in MET data (b), respectively. Kaplan–Meier plot analyses for subtypes identified by NMF clustering of the CNVcor and METcor genes are shown for overall survival (OS) and time to tumor recurrence (TTR), respectively. c Heatmaps show the expression patterns of subtypes identified by iCluster analysis. The subtypes identified by the CNVcor or METcor genes using NMF cluster methods are indicated with colored bars (top). The frequencies of aberrant expression of CNVcor_UP, CNVcor_DOWN, METcor_UP, and METcor_DOWN genes in each subtype are shown (bottom). d Kaplan–Meier plot analyses for subtypes identified by iCluster (iCl1, iCl2, and iCl3) are shown for overall survival (OS) and time to tumor recurrence (TTR), respectively