Fig. 2 | Nature Communications

Fig. 2

From: Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Fig. 2

pH-dependent nanoparticle decomposition and drug behaviors of H-MnO2-PEG/C&D. a TEM images of H-MnO2-PEG after incubation in buffers with different pHs (7.4 and 5.5) for various periods of time. b The degradation behavior of H-MnO2-PEG dispersed in different pH values (7.4, 6.5 and 5.5) determined by the absorbance of MnO2. c Pore-size distribution curve and N2 adsorption/desorption isotherms (inset) of the H-MnO2-PEG sample. d Ce6 and DOX-loading weight ratios in H-MnO2-PEG/C&D at different feeding drug: MnO2 ratios. e UV–vis-NIR spectra of free Ce6, DOX, H-MnO2-PEG, and H-MnO2-PEG/C&D. f Percentages of released Ce6 and DOX from H-MnO2-PEG/C&D over time in the presence of 10% fetal bovine serum (FBS) at different pH values (7.4, 6.5, and 5.5). Date are presented as means ± standard deviation (s.d.) (n = 3)

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