Fig. 3 | Nature Communications

Fig. 3

From: Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Fig. 3

In vitro experiments with H-MnO2-PEG/C&D. a A scheme illustration of H-MnO2-PEG/C&D for pH-responsive drug delivery and oxygen-elevated PDT. b The O2 concentration changes in H2O2 solutions (100 μM) after various concentrations of H-MnO2-PEG/C&D were added. c In vitro PDT treatment of 4T1 cells by free Ce6 or H-MnO2-PEG/C under 660-nm light irradiation (5 mW cm−2 for 30 min) in N2 or O2 atmospheres. d Confocal images of 4T1 cells treated with H-MnO2-PEG/C&D at different times points. Blue, green, and red represent DAPI, Ce6, and DOX fluorescence, respectively. e Relative viabilities of 4T1 cells after incubation with H-MnO2-PEG/C with light irradiation, or H-MnO2-PEG/C&D with or without 660-nm light irradiation (5 mW cm−2, 30 min). Date are presented as means ± s.d. (n = 5)

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