Fig. 7
The abscopal effect of H-MnO2-PEG/C&D in combination with anti-PD-L1 (α-PD-L1) checkpoint blockade. a Schematic illustration of H-MnO2-PEG/C&D and anti-PD-L1 combination therapy. b, d Primary (b) and distant (d) tumors growth curves of different groups of mice after various treatments indicated. Error bars are based on SEM (six mice per group). The arrows represent the time points of anti-PD-L1 administration. c, e Average weights of primary (c) and distant (e) tumors collected from mice 18 days after initiation of various treatments. f CTL infiltration in distant tumors. CD3+CD8+ cells were defined as CTLs. g The production of TNF-α in sera of mice determined on the 9th day post various treatments. h The proposed mechanism of anti-tumor immune responses induced by H-MnO2-PEG/C&D in combination with anti-PD-L1 therapy. p values were calculated by Tukey’s post-test (***p < 0.001, **p < 0.01, or *p < 0.05)
