Fig. 8
Eliminating cis P-tau in rmTBI mice with cis mAb prevents the development of clinically relevant functional deficits. Cis mAb treatment of rmTBI mice prevents sensorimotor coordination deficits, as detected by Ledge assay a, string suspension b and accelerated rotarod c, and urinary incontinence, as assayed by spontaneous urinary pattern analysis d, e and memory deficit, as assayed by novel object location recognition test at 6 months after injury f, g. 5−6 mice underwent urinary pattern test and 9−10 WT mice underwent other behavioral studies per group. The data are presented as means ± SEM. The p-values were calculated using unpaired two-tailed parametric Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001
