Table 1 Optimization of reaction conditions

Reactions were run using 1a (0.15 mmol), 2 (0.30 mmol), catalyst (0.015 mmol), and solvent (0.30 ml). Yields represent material isolated after silica gel column chromatography. Diastereomeric ratios (dr) were determined by ¹H NMR spectroscopy
^aReaction was run using trimethylsilyl cyanide (0.30 mmol) with 2-propanol (0.30 mmol) instead of 2
^bReaction was run using trimethylsilyl cyanide (0.30 mmol) instead of 2
^cReaction was run using 0.18 mmol of 2 and 0.0075 mmol of 4a for 48 h
^dValues are for minor diastereomers

Quick links

Search