Fig. 1
ACC display a high-mutational load and specific mutational signatures. a Number of mutated genes per tumor detected by WES. b Genes with most recurrent, however, still low frequency point mutations in ACC. c Comparison of WES results to published studies12, 13 of ACC shows a similar low frequency of recurrent mutations. Both published studies12, 13 were utilized as a comparison in combination as one of them only contained three ACC. d Mutational pattern of ACC. The type of base substitution in their genomic context (base preceding and base following) is displayed. e Published mutational signatures27 present in each sample is displayed. Associations of signatures: signature 1: deamination of 5-methylcytosine, signature 4: tobacco smoking, signature 29: tobacco chewing, signature 3: DNA double-strand break repair defects, signature 6: defective DNA mismatch repair and microsatellite unstable, signature 15: defective DNA mismatch repair, signature 20: defective DNA mismatch repair
