Fig. 4

Frequent molecular alterations can be identified in ACC. a Circos plot displaying all autosomes (outer circle, grey, centrosomes red) with amplifications (middle circle, red), deletions (middle circle, blue), hypermethylation (inner circle, green), hypomethylation (inner circle, yellow). b Heatmap of top 100 genes encompassing copy number aberrations and differential promoter methylation; red: leading to loss of gene function, blue: leading to gain of gene function. The darker the color the more aberrations were detected