Fig. 5

ID3, ARID1A, APC, and CDKN2A are downregulated in the vast majority of ACC. a representative IHC for tumor and normal tissue; scale bar corresponds to 100 μm; all microscopy images are shown at the same magnification. b Percentages of altered tumors in cohort 1 and cohort 2, a total of 69 tumors were investigated. c Overview of co-occurrence of protein alterations. d Venn diagram of co-occurrence of protein alterations. e IHC in combination with 450K data: co-occurrence of (epi-)genetic and protein alterations, grey: no data available