Table 1 Combined PTEN loss and SHQ1-FOXP1 loss is associated with recurrence in primary prostate, breast, and head and neck cancer by multivariate Cox regression in TCGA cohorts
From: Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis
Cancer cohort | P-value | Hazard ratio | 95% CI for HR | |
|---|---|---|---|---|
| Â | Â | Â | Lower | Upper |
Prostate cancer (TCGA cohort) | ||||
 Indicator (neither FOXP1 nor PTEN loss) | NS |  |  |  |
 FOXP1 loss only (expression z < −1 or hemizygous or homozygous loss) | NS | 0.607 | 0.179 | 2.061 |
 PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss) | NS | 0.779 | 0.289 | 2.103 |
 Both FOXP1 and PTEN loss | 0.029 | 2.805 | 1.112 | 7.075 |
Breast cancer (TCGA cohort) | ||||
 Indicator (neither FOXP1-SHQ1 nor PTEN loss) | NS |  |  |  |
 FOXP1-SHQ1 loss only (expression z < −1 or hemizygous or homozygous loss) | NS | 1.190 | 0.563 | 2.515 |
 PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss) | NS | 1.562 | 0.858 | 2.843 |
 Both FOXP1-SHQ1 loss and PTEN loss | 0.042 | 2.059 | 1.028 | 4.123 |
Head and neck cancer (TCGA cohort) | Â | Â | Â | Â |
 Indicator (neither FOXP1-SHQ1 nor PTEN loss) | NS |  |  |  |
 FOXP1-SHQ1 loss only (expression z < −1 or hemizygous or homozygous loss) | NS | 1.970 | 0.977 | 3.974 |
 PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss) | NS | 1.359 | 0.297 | 6.220 |
 Both FOXP1-SHQ1 loss and PTEN loss | 0.048 | 2.144 | 1.006 | 4.570 |
