Fig. 4

PAX7 target gene repression is an equivalent FSHD biomarker to DUX4 target gene expression. a A ROC curve compares the discriminatory power of our PAX7 biomarker with the DUX4 target gene signature that we derived from Geng et al.³⁵, across five microarray data sets (in total n = 82 FSHD and n = 82 control muscle biopsies). De-Long’s test p-value is given and demonstrates that the PAX7 biomarker is a significantly better discriminator of FSHD status. b A ROC curve compares the discriminatory power of our PAX7 biomarker with the DUX4 target gene signatures that we derived from Geng et al.³⁵ and Choi et al.³⁴ and that described in Yao et al.¹⁰ across the RNA-seq data set of n = 15 FSHD and n = 8 control muscle biopsies. De-Long’s test reveals no significant differences in the discriminatory power of these four biomarkers