Fig. 2
From: Structural basis of arrestin-3 activation and signaling
The phosphate and activation sensors in IP6-activated arrestin-3. a Conformation of the lariat loop in IP6-activated arrestin-3 disrupts the polar core. b Conformation of the lariat loop in basal arrestin-3 (PDB 3P2D6) with an intact polar core. c Helical conformation of the finger loop stabilized by the active arrestin-3 trimer. d Similar hydrophobic contacts are observed in the arrestin-1-rhodopsin interaction (4ZWJ13), and have distances of 3.5–4 Å between hydrophobic side chains
