Fig. 4
From: Structural basis for GPR40 allosteric agonism and incretin stimulation
X-ray crystal structures of human GPR40-TAK-875 (PDB: 4PHU) and GPR40-compound 1 complexes. a GPR40 (gray ribbon) in complex with TAK-875 (green stick) in site A1. Monoolein is modeled in site A2 (yellow stick) in 4PHU. b, GPR40 (cyan ribbon) in complex with compound 1 (orange stick) in site A2. Transmembrane helices H3, H4, H5 and intracellular loop 2 (ICL2) are labeled. Phospholipids are rendered as balls and lines, illustrating the transmembrane region of the receptor. The Fo-Fc omit maps of TAK-875, monoolein, and compound 1 were calculated in their absence and are shown as black mesh and contoured at 3.0 σ. Figures were prepared using PyMOL (Schrödinger, New York). Stereo image of b is provided in Supplementary Fig. 8
