Fig. 7
From: Structural basis for GPR40 allosteric agonism and incretin stimulation
Site A2 as a possible free fatty acid binding site. Chemical structure of: a compound 1; b AM-1638; c γ-linolenic acid (γ-LA). Some of the atoms are numbered to show length similarity between compound 1, AM-1638, and γ-LA. d Structural superposition of 4PHU with the GPR40-compound 1 complex (Cα RMSD = 0.99 Å) in ribbon representation. 4PHU is in white with TAK-875 shown in green as space-filling representation. GPR40-compound 1 structure is in cyan, and compound 1 in site A2 is replaced by a model of γ-LA in yellow as space-filling representation. The A2 binding pocket is rendered as Connolly analytic surface44, colored based on electrostatic potential (red: negative; blue: positive; white: neutral)
