Fig. 7
From: Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Endogenous protein polysulfidation in vivo and in HEK293T cells. The amounts of CysSSH formed in whole cell protein recovered from the mouse livers of WT and Cars2 +/− (line 1) 21-week-old male littermates (a) and from WT and CARS2 KO HEK293T cells (b) were quantified by using HPE-IAM labeling LC-MS/MS analysis. Data are means ± s.d. (n = 3). *P < 0.05; **P < 0.01. c Schematic drawing of the mechanism of the extramitochondrial release of CysSSH into the cytosol, which may regulate whole cell protein polysulfidation
