Fig. 8 | Nature Communications

Fig. 8

From: Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

Fig. 8

Models for shelterin search mechanism for telomeric 3′ end and telomerase recruitment based on the shelterincore complex. a A model for shelterin positioning at the telomeric 3′ end suggests a shelterin complex such as shelterin(core) would first localize to a ss/ds telomeric DNA junction via TRF2 and POT1 binding (shown here via internal ss-telomeric region). Then the POT1 component would seek the higher affinity 3′ TTAG end, thus protecting the chromosome end. b Dual pathways exist for TPP1 tethering to telomeres, either via TIN2–TRF2 or via POT1, both of which would facilitate telomerase recruitment and its processivity

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