Fig. 1

Simulated parasitaemia within individual patients. Here we show example model output for the parasite density (the number of parasitised red blood cells per µL) over time. Our within-host parasitaemia model was fitting to data from 35 malaria therapy patients, as described in the ‘Methods’ and Supplementary Methods section. a Untreated infections, where each different coloured line represents a different patient. These three model simulations were selected to demonstrate the variety of infection duration generated by the model. b Treated infections in 1000 simulated patients treated with six doses of AL, with the median parasitaemia at each two-day time point shown in black. Treatment fails in about 5% of cases (here coloured blue), causing patients to relapse