Table 2 Regression analysis of model results

From: Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling

Variable

Odds ratio

95% confidence interval

p-value

Population model (n = 482)

 Proportion of prescribed pills taken

0.00971

(0.00738,0.0128)

<0.0001

Subset Model (n = 305)

 Sum of [Actual minus recommended dose time] (in hours)

1.009

(1.007,1.012)

<0.0001

 All Doses Timely

0.827

(0.731,0.936)

0.003

  1. Predictors of treatment failure (measured at day 28) in our simulation model, based on patterns of adherence found in the individual-level data. Regression was performed using logit-transformed predicted treatment failure probability as the outcome. In model A all 482 patients were considered. A long gap between doses (>24 h) and all doses being timely (within 4 h of the recommended time) did not improve the model fit and were discarded. In Model B, we only assessed patients who had taken all prescribed pills in six doses. The categorical variable for a long gap between doses did not improve the model fit
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