Fig. 2
From: Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
Global and significant post-transcriptional regulations revealed by proteomic data. a Correlation analysis between mRNA abundance and total protein levels upon T21 revealed a moderate correlation across levels, and weak association regarding cross-layer effects of T21, reflected by matching unrelated samples. b Same analysis to a but in twin samples. c T21 transcript signatures discovered in fibroblast cells of Sullivan et al.5 are conserved between cell types and impact protein levels. d Volcano plots were generated for twin samples (three aliquots of T1DS vs. three aliquots of T2N), three pairs of T21, and N samples (unrelated) and the whole unrelated sample set (11 T21 vs. 11 N). Rep1 and Rep2 mean two independent twin cell cultures. Red circles denote significant proteins of >1.5-fold change (FC) at P < 0.05 (Student’s t test). The highlighted yellow circles denote Chr21 proteins
