Fig. 3
From: Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
Chr21 protein expression and primary dosage compensation. a Correlation analysis between absolute and relative changes between mRNA, protein, K deg for global proteome, proteins encoded by Chr21 and other chromosomes. N.S., not significant. b Hierarchically clustered heatmap of FC for mRNA, protein, and K deg. The red and green colors represent “complex_in” and “complex_out” groups, respectively. N.D., not detected. c The dosage compensation against aneuploidy through protein complex stoichiometry control remained apparent at mRNA, protein, and K deg data levels, and is confirmed by the samples from unrelated individuals. N = 18 and 24 for complex_in and complex_out groups from Ch21 and N = 1906 and 2068 for those from other chromosomes (Other Chrs). d Binary log2 fold changes (N = 121 comparisons) of Chr21 protein expressions between unrelated individuals. The red and green colors represent “complex_in” and “complex_out” groups. In all box plots (Methods), the borders represent the 25th and 75th quantile, respectively, and the bold bar represents the 50th quantile. Wilcox test was used to infer P-values. Standard gene symbols are used, with corresponding SwissProt IDs listed in Supplementary Data 2
