Fig. 4
From: Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
Significantly regulated proteins and their network associated to T21. Proteins in the reactome pathways that were found to be significantly enriched (P < 0.01, see Methods for details) are represented as a network graph, where edges indicate functional connections, i.e., links between proteins in same reactome pathways. Nodes represent individual proteins and these are colored according to a dominant reactome pathway annotation. If the protein is upregulated, its node border is black, if it is downregulated it is light gray. Names of the proteins encoded by the genes on the chromosome 21 are shown in red
