Fig. 7

Co-regulation of mitochondrial protein complexes in T21. Co-regulation of mitochondrial complexes starts at the transcriptional level and gets uniform at protein level through protein level regulation and protein degradation processes. Proteins belonging to Complexes I–V are visualized by the nodes with shapes of circle, hexagon, rectangle, triangle, and diamond, respectively. The edges between nodes denote high-confidence protein interactions documented in STRING database (minimal combined score >0.45). In the visualization panels of mRNA, protein, and K _deg comparisons, the node size is proportional to the log₁₀ scale transformed protein copies. The color gradient of blue–yellow–red depicts the log₂ T1DS/T2N FC values. Standard gene symbols are used, with corresponding Swissprot IDs listed in Supplementary Data 2. The Western blots were performed for selected proteins in each mitochondrial protein complex, confirming their downregulations in T1DS