Table 2 Mixed linear regression model estimates for ACTH concentrations (ng/ml) measured in diluted medium samples from cells transfected with KCNQ1

From: Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis

Parameter

Estimate

SE

p

Intercept (WT KCNQ1)a

7.26

0.99

<0.001

Time

0.76

0.25

0.004

KCNQ1-Arg116Leu

0.32

0.72

0.659

KCNQ1-Pro369Leu

0.62

0.72

0.393

KCNQ1-Gly589Asp

1.11

0.72

0.126

  1. Mixed linear regression model estimates for ACTH concentrations (ng/ml) measured in diluted medium samples (1:10) in the reference condition (WT KCNQ1) and three other KCNQ1 conditions (KCNQ1-Arg116Leu, KCNQ1-Pro369Leu, KCNQ1-Gly589Asp), their standard errors (SE), and corresponding P values. The model included both the growth time (per 1 h) and the KCNQ1 conditions as fixed effects and the experiment number as a random intercept. ACTH levels produced by the cells transfected with mutant KCNQ1s did not differ from the levels produced by the WT KCNQ1. Similarly, the CRF-induced ACTH secretion did not differ between the four KCNQ1 environments (data not shown)
  2. aAt −2 h
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