Table 2 Differentially expressed targeted metabolites from the PVC of APOE4 vs. APOE3 mice

From: Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

Metabolite

Regulation in E4/4

Fold change

P-value

FDR

Detection mode

CAS number

Fatty acids

 Gamma-linolenic acid

Down

1.19

0.003

0.068

Positive

506-26-3

 Palmitic acid

Down

1.32

0.021

0.212

Negative

57-10-3

 10-Hydroxydecanoate

Up

2.22

0.015

0.195

Positive

1679-53-4

 Docosahexaenoic acid

Down

2.03

0.021

0.212

Negative

6217-54-5

 Arachidonic acid

Down

1.45

0.021

0.212

Negative

506-32-1

Oligosaccharides

 Trisaccharide

Up

1.82

0.015

0.212

Negative

 

 Tetrasaccharide

Up

2.70

0.021

0.212

Negative

 

Vitamin and vitamin derivatives

 Dehydroascorbic acid

Up

2.03

0.001

0.062

Positive

490-83-5

 Phylloquinone

Up

1.90

0.001

0.062

Positive

84-80-0

 Ascorbic acid

Up

105.84

0.005

0.192

Negative

50-81-7

 Tocopherol

Up

2.28

0.008

0.192

Negative

59-02-9

Energy-related metabolites

 Acetylcarnitine

Up

1.40

0.003

0.068

Positive

3040-38-8

 Carnitine

Up

1.31

0.011

0.154

Positive

541-15-1

 Coenzyme A (CoA)

Up

2.82

0.028

0.282

Positive

85-61-0

 Pyruvate

Up

1.43

0.028

0.238

Negative

127-17-3

Cholesterol metabolites

 Taurodeoxycholate

Up

1.94

0.003

0.068

Positive

516-50-7

 Cholesteryl acetate

Up

2.24

0.008

0.192

Negative

604-35-3

 Lanosterol

Up

2.50

0.011

0.192

Negative

79-63-0

Amino acids

 Tyrosine

Up

1.25

0.037

0.270

Negative

60-18-4

 Serine

Down

1.18

0.049

0.270

Negative

56-45-1

 Glutamate

Down

1.08

0.049

0.282

Positive

56-86-0

Cysteine and methionine metabolites

 Pterin

Down

3.91

0.002

0.192

Negative

2236-60-4

Histidine metabolites

      

 Urocanic acid

Down

1.34

0.021

0.212

Negative

104-98-3

 Carnosine

Up

1.32

0.028

0.282

Positive

305-84-0

Arginine and proline metabolites

 Phosphocreatine

Up

1.62

0.037

0.282

Positive

67-07-2

 4-Guanidinobutyric acid

Down

1.09

0.049

0.270

Negative

463-00-3

Threonine metabolites

      

 2-Ketobutyric acid

Up

1.43

0.021

0.212

Negative

600-18-0

Tyrosine metabolites

      

 Homovanillic acid

Down

1.30

0.049

0.270

Negative

306-08-1

Riboflavin metabolites

 2,4-Dihydroxypteridine (lumazine)

Up

2.07

0.008

0.154

Positive

487-21-8

 Flavin adenine dinucleotide (FAD)

Up

1.19

0.021

0.212

Negative

146-14-5

 Lumichrome

Down

1.71

0.049

0.282

Positive

1086-80-2

Pyrimidine metabolites

 2-Aminoisobutyric acid

Up

1.38

0.011

0.154

Positive

62-57-7

 UMP

Up

1.22

0.049

0.270

Negative

58-97-9

 CMP

Up

1.29

0.049

0.282

Positive

63-37-6

Miscellaneous

 Lipoic acid

Up

3.76

0.005

0.192

Negative

1077-28-7

 Thiourea

Down

1.45

0.008

0.192

Negative

62-56-6

 Butyrylcarnitine

Up

1.24

0.011

0.154

Positive

25576-40-6

 Hydroxybutyric acid

Up

1.49

0.011

0.192

Negative

 

 Indoxyl sulfate

Down

2.12

0.021

0.212

Negative

2642-37-7

 3-Hydroxymethylglutaric acid

Up

1.27

0.028

0.238

Negative

503-49-1

 2-Hydroxypyridine

Up

1.45

0.037

0.282

Positive

142-08-5

 Maleic acid

Up

1.92

0.037

0.270

Negative

110-16-7

 N-Acetylneuraminic acid

Up

1.17

0.037

0.282

Positive

131-48-6

 N-Methylglutamic acid

Down

1.19

0.049

0.270

Negative

35989-16-3

 Cytidine diphosphate choline (CDP choline)

Down

1.17

0.049

0.282

Positive

987-78-0

 Glutathione

Up

1.49

0.049

0.282

Positive

70-18-8

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