Fig. 8 | Nature Communications

Fig. 8

From: Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5

Fig. 8

Model of RidL displacement of TBC1D5. RidL9–258 binds to Vps29 and displaces TBC1D5 from the retromer. (I) Retromer (Vps29-Vps35-Vps26) and TBC1D5 are recruited to the membrane by activated GTP-bound Rab7; cargo is recruited by the retromer. (II) In absence of RidL TBC1D5 leads to GTP hydrolysis and release of Rab7, whereas in presence of RidL TBC1D5 is displaced from Vps29, and retrograde trafficking is blocked by an unknown mechanism. (III) Retromer interacts with membrane-deforming sorting nexin (SNX) dimers. (IV) Transport tubules are formed involving other factors not shown here for simplicity

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