Fig. 7
From: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway
GWAS results for glycan ratios. a Reference pathway for interpreting the GWAS results. Black lines represent reactions in the known IgG glycosylation pathway, green lines represent reactions associated with the predicted rules, and gray lines represent possible reactions that were not selected by our approach. b–d GWAS results for IgG1, IgG2, and IgG4, respectively. Solid thick arrows represent ratios that were significantly associated with SNPs in the regions coding for an IgG glycosylation enzyme (P < 5.26 × 10−10 and p-gain > 10). Dashed arrows represent suggestive associations (5.26 × 10−10 ≤ P ≤ 10−7 and p-gain > 10). Gray nodes in the IgG4 plot represent glycoforms that were not measured. The asterisk indicates that the ratio was unexpectedly associated with SNPs in the FUT8 gene region
