Fig. 5
From: Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
Monocytic MDSCs mobilization is dependent on STING and type I IFN signaling after irradiation. a Representative flow gating chart. b Quantification of Ly6chi population in tumors in WT and STING−/− mice. c Activation of STING pathway by IR or by cGAMP administration can increase the recruitment of CCR2+Ly6chi cells. d Quantification of the CCR2+Ly6chi population in tumors grown in WT control, IR and IR + anti-IFNaR1 treated mice. e Type I IFN induces expression of CCL2 and CCL7 in tumor cells and CCL12 in host cells (n = 4); *P < 0.05; **P < 0.01; ***P < 0.001. Each experiment was repeated four times. Data are presented as mean ± s.e.m
