Fig. 6 | Nature Communications

Fig. 6

From: Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Fig. 6

Combined chromatin segmentation enrichment. Overlap of HSM peaks with combined chromatin segmention functional annotations. Seven functional categories are included in the combined algorithm: PF promoter flanking, TSS transcription start site, CTCF, WE weak enhancer, E enhancer, T transcribed region and R repressed. Size of circle as a proportional adjustment to genome size (~10(Region Proportion)). a Proportional overlap with HSM peaks and Genome (non-overlapping 500 bp windows, minus blacklist regions). Highlighted region in grey dashed box displayed in b. c Proportional overlap with HSM peaks and GWAS LD blocks (non-overlapping 500 bp windows, minus blacklist regions). Highlighted region in grey dashed box displayed in d. Graphs are adapted from Epiexplorer71

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