Fig. 8 | Nature Communications

Fig. 8

From: Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway

Fig. 8

Working model. In this study, we demonstrate that Plk1 interacts with and directly phosphorylates G6PD to promote the formation of its active dimer, thereby enhancing PPP flux and macromolecule biosynthesis. Together with previous reports that have established multiple critical roles for Plk1 in regulation of mitosis and cell cycle progression, we propose that Plk1 coordinates biosynthesis with cell cycle progression to promote cancer development

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