Fig. 5
From: Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
Literature, vendor, and cheminformatics analyses of reported HAT inhibitors show concerning trends. a Many HAT inhibitors are highly prevalent in the scientific literature. Shown are the number of reviews (blue subset), non-reviews (red subset), and total unique citations (red plus blue subsets) cataloged in the SciFinder® database for the original reports of compounds 1–23 as HAT inhibitors. Data accessed 03 June 2017. b Most HAT inhibitors are widely commercially available. Shown are the number of vendors listing compounds 1–23 for purchase according to the SciFinder® database, either in-stock or synthesis-on-demand. Data accessed 03 June 2017. c Analysis of original publications for compounds 1–23 shows common experiments for compound selectivity, mechanism of action, assay interference, target engagement, and purity/identity are not routinely performed. d Many of the reported HAT inhibitors tested have poor calculated physicochemical properties (logP, APT)
