Table 1 Summary of assay interference for reported HAT inhibitors

From: Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

  1. aCommon names in parentheses; references for each reported HAT inhibitor are listed in Supplementary Table 1. An expanded data table is also provided (Supplementary Data 1)
  2. b(+) DTT, 25 mM DTT present; (−) DTT, 0 mM DTT present; +, positive readout; −, negative readout; /, partial-positive readout; see also Fig. 1; most compounds were tested by two or three independent experiments and yielded similar results
  3. c+, adduct detected; −, no adduct detected; I, indeterminate; ND, not determined; see also Methods section for additional interpretation
  4. d(*, *), (DTT present, DTT absent); 250 μM test compound concentration; ND, not determined; see also Supplementary Fig. 5
  5. e+, detergent-sensitive; −, detergent-insensitive; + (A), detergent-sensitive activation; see also Fig. 2b
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