Table 1 In vitro inhibition of translation measured in L. tarentolae a, E. coli b, and rabbitc reticulocyte lysates

From: Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

Inhibition of translation—IC50 (μM)

 

Leishmania a

Bacteriab

Reticulocytesc

G418

0.153 ± 0.0356

0.009 ± 0.00159

2 ± 0.39

GEN

18.41 ± 3.139

0.028 ± 0.004

62 ± 9

PAR

3.62 ± 0.176

0.051 ± 0.0059

57 ± 49

NEO

82.36 ± 2.139

0.011 ± 0.001

28 ± 5

APR

200.6 ± 16.12

0.049 ± 0.003

29 ± 6

HYG

0.0647 ± 0.0053

0.011 ± 0.002

0.8 ± 0.1

  1. Each value represents the mean ± SE of at least three independent repeats
  2. G418, geneticin; GEN, gentamicin; PAR, paromomycin; NEO, neomycin; APR, apramycin; HYG, hygromycin B
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