Table 1 EC50 values of carolacton on human cancer cell lines
From: The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
Cell line | EC50 (µM) | Maximum inhibition |
|---|---|---|
HCT-116 | 24.6 ± 0.8 | >80% |
KB-3.1 | 11.3 ± 3.6 | >80% |
KB-V.1 | 41.8 ± 14.5 | >80% |
U-937 | >100 | n.a. |
U-937 (folate-depleted) | 41.7 ± 15.2 | 65–75% |
