Fig. 3
Comparison of mutational patterns of different ESCC patient populations. a Distribution of depth of coverage of exons captured in WES. Chinese tumors and matched normal tissues had higher depth of coverage than those of TCGA ESCC cases before downsampling. After downsampling, the three patient cohorts had similar distributions of depth of coverage. b The number of somatic mutations for each patient cohort before and after downsampling. The error bars and numbers on the top of the bars were calculated based on mutation calls from 10 downsampling iterations. c Box plots showing the distribution of the number of somatic mutations in each sample in the three cohorts before and after downsampling. The center lines in the boxes are the median numbers of somatic mutations for different patient cohorts, while the upper and lower hinges are the 25th and 75th percentiles. Whiskers above and below the boxes indicate 1.5 times interquartile range. Individual points are those outside of the range. d Mutational signature of each cohort after downsampling
