Fig. 2
From: Structural basis for the assembly of the Ragulator-Rag GTPase complex
Assembly of p14-MP1 and p10-HBXIP heterodimers. a The orientations of roadblock heterodimers upon formation of the heterotetramer in the structure of Ragulator. The β1–β2 loop near the two helices docks into the groove formed by the α3 helix on the side of four helices. b Ribbon model representation of interactions between p14-MP1 and p10-HBXIP roadblock dimers (left panel). The structure is viewed from different angles rotated at 160° along the vertical axis (right panel). Hydrogen bonds are shown as black dashed lines. c Ribbon model representation of the p10-HBXIP dimer superimposed on the p14-MP1 dimer (left panel). The structures of each dimer are viewed from different angles rotated at 60° along the horizontal axis (right panel). The groove formed in the p10-HBXIP dimer is shown as circled. d Ribbon model representation of p18 superimposed on p14, MP1, p10, and HBXIP. Molecular surface models are also superimposed
