Fig. 1

DNA methylation in context of genetic determination. a Distribution of the degree of methylation (β-value) of CpGs. The 14,118 meQTL-CpG sites display a rather intermediate distribution of their median β-values (red) compared to the bimodal distribution observed for all 344,106 CpG sites (black). b The relationship of explained variance R 2 to the genomic distance of 14,118 meQTL-SNPs and their associated CpG site